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Product description
| Host | rabbit |
|---|---|
| Antibody Type | polyclonal |
| Immunogen | porcine VIP |
| Purification | stabilized antiserum |
| Conjugate | unconjugated |
| Formulation | contains 0.09% sodium azide |
| Storage | short term at 2-8°C; long term storage in aliquots at -20°C; avoid freeze/ thaw cycles |
| No. of experiments | ≤ 500 (IHC, 50 µl/slide) |
| Note | centrifuge prior to opening |
| Intended use | Research use only |
| Tested species reactivity | human, mammals |
Applications
| Tested applications | Tested dilutions |
|---|---|
| Immunocytochemistry (ICC)/ Immunofluorescence (IF) | assay dependent |
| Immunohistochemistry (IHC) - frozen | 1:50 – 1:100 |
| Immunohistochemistry (IHC) - paraffin | 1:50 – 1:100 |
Background
Details
Located in the nerve fibers in the central and peripheral nervous system, VIP is probably acting as a neurotransmitter. The Verner-Morrison or Water Diarrhea Hypokalemia and Achlorhydria (WDHA) syndrome is a characteristic clinical syndrome associated with overproduction of VIP from endocrine tumors.
VIP-producing tumors are usually neuroblastomas or endocrine tumors in the pancreas. The localization of the antigen is extracellular and cytoplasmic.
Recommended for positive control: Ileum
Reference
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