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comprise three variants of desmocollin (DSC1-3) and four variants of desmoglein (DSG1-4).

are associated to desmoplakin.

Additionally, the transcellular adherence between desmocollin and desmoglein is Ca2+ dependent.

Therefore, they are described as desmosomal crosslinkers.

Moreover, it is an essential component of the desmosome due to its role in linking the desmosomal plaque

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Job Description

Autophagy was first described as primordial degradation pathway to protect cells from starvation by maintaining

Amongst others, it plays an important role during infection, targeting pathogens for degradation and

is strongly involved in the repair mechanism of the cell by degrading defective organelles, membranes

and proteins.Several human diseases have also been described to be associated with defects of the autophagy

death and morbidity.

of different brain tumors can develop and interfere with proper function of the brain.

disease develop with age and others are genetic predispositions.

tumors described.

The primary brain tumors are tumors that develop in the brain itself and can have a rather poor prognosis

  Sevral markers have been described to be relevant brain tumor markers for exmaple p53, synaptophysin

The absence of any symptoms or human disease being associated with AAVs makes AAV derived vectors a perfect

vehicle for the delivery of genetic material to human cells.

Therefore, AAV vectors are suitable for in vivo gene delivery.

only need to be delivered once.

adenovirus- and retrovirus-derived vectors.

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Cell growth and cell division are highly regulated basic mechanisms which play essential roles in cell

While the cell cycle defines the process by which a cell divides in two daughter cells, cell proliferation

describes the major mechanism of tissue development and regeneration.

The DDDDK sequence is part of the Flag-tag (patented by Sigma Aldrich).Consists of 8 aa (DYKDDDDK), barely

affects protein structure or functionAdded to N- or C-terminus (slightly beneficial at N-terminus)Detection

in vivo & in vitro, 3x FLAG systems improves detectionPurification (non-denaturing e.g. by antibody-mediated

Not suitable for purification of high amounts but for isolation with high purityVery stable & not degraded

so called Flag-tagHigh affinity & robust detectionSuitable for ICC/IF, IP & WBAlso available

PROGEN uses Priority Delivery Service Federal Express (FedEx) or other carriers for international shipments

We ship our products directly from our warehouses in Germany or USA within 3 working days after receipt

Shipping time depends on the country of destination.DestinationDelivery TimeGermany1-3 working days*EU

, Switzerland, Norway    3-5 working days*USA, UK3-7 working days* (plus clearance through

customs)Other3-7 working days* (plus clearance through customs)* Shipments on dry ice or on freeze

Techniques OptiPrepTM is used for different density gradient designs including discontinuous or continuous

gradients due to its high density.

Starting with the densest solution and continuing to layer solutions of successively lower densities

Starting with the lowest density solution and underlaying successively denser solutions beneath the lighter

their density.

Spot landing in the optimal dynamic range Most accurate capsid titer determination methods, for example

the AAV ELISA, have a specific dynamic range.

But, by using the AAV Dip'n'Check tests to determine the titer of an unknown sample, you are able to

Therefore, a dilution range between 1:25,000 to 1:100,000 allows you to hit the optimal dynamic range

to determine the accurate titer required for the AAV ELISA.

relevant data protection declarations.The legal basis for the processing of personal data is, depending

is based on the use of standard contractual clauses according to the European Commission: https://de-de.facebook.com

countries is based on the use of standard contractual clauses according to the European Commission: https://de-de.facebook.com

of targeted advertising and the targeted design of our fan page.

as a visitor can be defined as processing.

Please use the following address for your payment: PROGEN Biotechnik GmbH Attn: Accounting Bank details

: Deutsche Bank, Heidelberg: Account 0369 009 (BLZ 672 700 03) IBAN: DE32 6727 0003 0036 9009 00 BIC

: DEUTDESM672 

days after delivery and of hidden defects no later than 5 working days after detection. 7.3 In the context

   8 Returns 8.1 If PROGEN, despite being under no legal obligation to do so, agrees to take

The products have to be sent “free destination”, DDP PROGEN Biotechnik GmbH, Maaßstra

The relevant restrictions may be found in the respective product description.

as described in said privacy policy.

kits for IHC, containing suitable blocking solution as well as the HRP-coupled secondary antibody for detection

Available as anti-guinea pig, anti-mouse and anti-rabbit detection kit. prohisto-HiVis: The prohisto-HiVis

contains the chemical substrate DAB (3,3´diaminobenzidine) for visualization of the detected target

Rapid AAV Titer Determination In both academia and industry, AAV is the most commonly used viral vector

for the delivery of therapeutic transgenes.

However, testing individual and crude AAV samples quickly during development and manufacturing is often

difficult.

A lateral flow sandwich assay for the semi-quantitative detection of fully assembled AAV capsids using

AlphaLISA® AAV2 Capsid Detection Kit PerkinElmer has integrated PROGEN’s well-established AAV2 particle

The AlphaLISA® AAV2 Capsid Detection Kit is designed to quantify AAV2 capsids in buffer, cell culture

media, cell lysates and cell supernatants.PROGEN’s A20R antibody exclusively detects fully assembled

There are several disorders that might develop in the aerodigestive tract including disorders in the

airway (pharynx & larynx), pulmonary tract (trachea, bronchi & lungs) and upper digestive tract

  Aerodigestive disorders can be congenital, developmental or acquired and the development can be

beside the improving diagnostic and therapeutic tools the prognosis remains poor.

HNSCCs usually develop in the tissue of the oral cavity, oropharynx, larynx or hypopharynx.

Common chronic inflammatory diseases of the digestive tract are ulcerative colitis and Crohn's disease

The marker calprotectin is of great importance for the detection and research of both diseases.

Colorectal cancer is also a common disease of the digestive tract and is an important research target

macromolecules in high yield and both research and clinical applications provide an impetus for the development

The media are used in density gradient separation for the purification not only of cells and organelles

Our density gradient media developed by Serumwerk Bernburg AG are: Proven to be non-toxic,

Have a low osmolality Are sufficiently dense to permit the purification of all types of biological

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Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells.

Deficiency of a Lipid Droplet Protein, Perilipin 5, Suppresses Myocardial Lipid Accumulation, Thereby

Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1a/SIRT1-dependent transcriptional regulation

AMPK-dependent phosphorylation of lipid droplet protein PLIN2 triggers its degradation by CMA.

Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins J Diabetes Res. (2017)

Cellular differentiation is a basic mechanism that occurs during embryonic development as well as tissue

The differentiation of a cell leads to major modifications in the gene expression leading to changes

These modifications in the gene expression occuring during cell differentiation are the focus of epigenetic

    View Cell Differentiation Antibodies

Along with post-translational modifications and structural reorganization of these proteins, a distinct

expression and organisational pattern of keratins is typical for the different epithelial tissues.

than 60 different disorders have been linked to inherited keratin changes.

epithelial disorders, including cancer.

These significant changes in Keratin distribution can be detected and investigated with PROGEN Keratin

Depending on the volume of reticulum cells and fat cells, bone marrow is divided into red and yellow

Although these cells are capable of division, they have little division activity, are undifferentiated

their differentiation possibilities decrease (committed progenitor cells, CFU).

Stage-specific combinations of various surface molecules, including CD45 isoforms, can be used to detect

stages of cell differentiation.

Genome titer - qPCR/dPCR Due to the high variabilities of PCR-based methods, the genome titer is determined

by three independent laboratories in an average of 15-20 different runs.

The AlphaLISA® AAV2 Capsid Detection Kit is designed to quantify AAV2 capsids in buffer, cell culture

media, cell lysates and cell supernatants.PROGEN’s A20R antibody exclusively detects fully assembled

Viruses differ fundamentally from true microorganisms and organisms in their composition and reproduction

Due to a lack of their own metabolism, viruses are obligate and depend on reproduction by host organisms

Viral reproduction does not take place through growth and division, but through replication of the viral

  Viruses can contain either DNA (deoxyribonucleic acids; DNA viruses) or RNA (ribonucleic acids

  Depending on their host specificity, viruses are divided into bacterial viruses (bacteriophages

Reliable AAV Capsid Titer determination Recombinant Adeno-Associated Virus (rAAV) vectors are increasingly

used for in vivo gene transfer to target inherited genetic diseases.

As the industry gold standard you can rely on PROGEN’s AAV ELISAs to consistently deliver dependable

capsid titer determination.

Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody.

Development of human-like scFv-Fc neutralizing botulinum neurotoxin E.

Development of recombinant antibodies for biodefense using phage display.

Development of human antibody fragments using antibody phage display for the detection and diagnosis

, Dübel S, Cha S, Wiersma E (2007) On the influence of vector design on antibody phage display.

Easy Four Step Workflow The AAV sample is pre-incubated with two differently conjugated AAV antibodies

Both AAV antibody conjugates delivered with this test are mixed in equal volumes with running buffer

  The Dip´n´Check AAV quick test is a semi-quantitative assay with a detection range

Within this range, a 2-fold concentration difference can clearly be detected.

There is no difference in the antibody affinity to empty and full capsids.   Download Workflow

Any organism that can cause a disease can be described as a pathogen, including bacteria and viruses

However, parasites do not belong to the group of pathogens.  View our Pathogen Antibodies

203 products found for "desmoplakin"