Antibodies

IIB5 reacts with BrdU in denatured (single-stranded DNA). Learn More

Recognizes a 180 kD band; no cross-reactivity with biliary glycoprotein and antigen 1/11 (NCA). Learn More

Specific for drebrin, a widespread actin-associating protein of 70 kD (SDS-PAGE mobility shows Mr 120,000), enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. Positive staining was found in many tissues. Especially prominent in the mesangial cells of renal glomeruli and in the Sertoli cells of testis. Negative: hepatocytes and cross-striated muscle. Learn More

Ep-CAM (homophylic cell-cell adhesion molecule, also named ESA, EGP40, 17-1A antigen, KSA, GA7333-2) is a 40 kD epithelial protein expressed on the baso-lateral cell surface of many epithelial tissues. Antibody stains most epithelial cells and carcinoma de-rived therefrom. Learn More

The antibody reacts with 170 - 220 kD cell surface glycoproteins (CD45), the Leukocyte Common Antigen (LCA), expressed selectively on hematopoietic cells. It gives a pronounced staining on formalin-fixed, paraffin-embedded cells, and can be used to differentiate between lymphomas and carcinomas. Learn More

Recognizes melanoma-associated antigen in melanoma cells and nevocellular nevi. Cross-reaction with carcinoids; no reaction with normal melanocytes or epithelium except for mast cells, histiocytes, bronchial glands. Learn More

In paraffin sectionsthe anti- myelin 2B5 antibody recognizes only myelin in the peripheral nervous system. On frozen tissue it also weakly stains myelin in the central nervous system. Exclusive reaction with myelin sheats. Learn More

The antibody recognizes a 38kD nucleolar protein (NO38) in Xenopus (also termed numatrin, B23, nucleophosmin, in other species). No-63 stains specifically the granular component of the nucleolus and small nucleolar dots in interphase cells. During mitosis the protein is localized accumulated around the condensed chromosomes. Learn More

Discrimination between ovarian and non-ovarian carcinomas. Most primary nonmucinous carcinomas are stained positive. A positive staining is found in the fallopian tube epithelium and follicular cells of the ovary. Learn More