Call +49 6221 8278-0

PROGEN - passion for research

close×

IHC of rat skin using anti-Desmocollin 1 antibody (Cat. No. 61092) (courtesy of J.Heß, University Hospital Heidelberg) Zoom

IHC of rat skin using anti-Desmocollin 1 antibody (Cat. No. 61092) (courtesy of J.Heß, University Hospital Heidelberg)

anti-Desmocollin 1 & 3 sample set

The anti-desmocollin 1 & 3 sample set provides antibodies directed against desmocollin 1 and 3 to evaluate their presence and status in IHC and WB. The set contains enough antibody to perform stainings on 6-12 sections per antibody.

highly_published external_validation
Cat. No.: 70034
Quantity:  600 µl each antibody

 

Cat. No. Product Name Reactivity Application
61092S anti-Desmocollin 1 mouse monoclonal, Dsc1-U100, purified, sample (ready-to-use) human, mouse, rat IHC, WB
61093S anti-Desmocollin 3 mouse monoclonal, Dsc3-U114, purified, sample (ready-to-use) human, mouse, rat IHC, WB

Price as configured: €74.00

Excl. Tax, excl. Shipping Cost

Call us now for more information on our products: +49 6221 8278-0

Any more questions?
PRODUCT REQUEST

Specifications

Product description

Immunogen see individual antibody datasheet for information about specific immunogens
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Number of experiments 6-12 sections per antibody
Note centrifuge prior to opening
Intended use research use only
Tested species reactivity see individual antibody datasheet

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen ready-to-use
Immunohistochemistry (IHC) - paraffin ready-to-use (microwave treatment recommended)
Western Blot (WB) assay dependent

Background

Details

As one of the stronger cell-to-cell adhesion types desmosomes allow cells to connect their intemediate filaments to those of neighboring cells. Therefore desmosomes can be found especially in cardiac muscle tissue, in bladder tissue and in epithelia, where the meachnical stress is quite high. As members of the cadherin super family, desmogleins and desmocollins thereby mediate adhesion at demosomes. Plakoglobin and the plakophilins on the other hand are members of the armadillo gene family and mediate the connection of the desmosome to desmoplakins that themselves mediate the connection to the cytoskeleton.

Mutations in these proteins or autoimmune reaction against them lead to severe diseases like arrhythmogenic right ventricular cardiomyopathy, Hailey-Hailey disease or striate palmoplantar keratoderma.

Furthermore the tissue-specific expression of desmosomal proteins is critical to tissue homeostasis. Missexpression of single components of desmosomes can lead to hyperproliferation and abnormal differentiation.

The anti-desmocollin 1 & 3 sample set provides antibodies directed against desmocollin 1 and 3 to evaluate their presence and status in IHC and WB.  The set contains enough antibody to perform stainings on 6-12 sections per antibody.

Set content:
Cat. No. 61092S, anti-Desmocollin 1 mouse monoclonal, Dsc1-U100, purified, sample (ready-to-use), 600 µl
Cat. No. 61093S, anti-Desmocollin 3 mouse monoclonal, Dsc3-U114, purified, sample (ready-to-use), 600 µl

Reference

Material safety data sheet

Please complete the form below to request a material safety data sheet

Personal Info

* Required Fields

Product Request

Personal Info

* Required Fields