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IHC of human beard hair, using anti-Keratin 71 antibody (Cat.No. GP-K6irs1) (courtesy of L. Langbein) Zoom

IHC of human beard hair, using anti-Keratin 71 antibody (Cat.No. GP-K6irs1) (courtesy of L. Langbein)

anti-hair Keratin sample set

The anti-hair Keratin sample set provides antibodies directed against Keratin K71, K72, K75, K82, K85 and K86 to evaluate the presence and status in IHC and WB.
The set contains enough antibody to perform stainings on 6-12 sections per antibody.

Cat. No.: 70022
Quantity:  600 µl each antibody

 

Cat. No. Product Name Reactivity Application
GP-K6irs1S anti-Keratin K71 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB
GP-K6irs2S anti-Keratin K72 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB
GP-K6hfS anti-Keratin K75 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB
GP-hHb2S anti-basic Hair Keratin K82 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB
GP-hHb5S anti-basic Hair Keratin K85 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB
GP-hHb6S anti-basic Hair Keratin K86 guinea pig polyclonal, serum, sample (ready-to-use) human, mouse IHC, WB

Price as configured: €184.00

Excl. Tax, excl. Shipping Cost

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Specifications

Product description

Immunogen see individual antibody datasheet for information about specific immunogens
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Number of experiments 6-12 sections per antibody
Note centrifuge prior to opening
Intended use research use only
Tested species reactivity see individual antibody datasheet

Applications

Tested applications Tested dilutions
Immunohistochemistry (IHC) - frozen ready-to-use
Western Blot (WB) assay dependent

Background

Details

Keratins are a large protein family. Expression and structure of its members is highly tissue and differentiation specific. As heteropolymers, keratins form intermediate filaments (IFs) with the primary task of providing a structural framework in epithelial cells that protects them from mechanical and non-mechanical stress. In addition, keratins are involved in establishing apico-basal polarization, regulating motility and cell size and even play a role in complex cellular events such as protein synthesis, membrane traffic or cell signaling.

The anti-hair Keratin sample set provides antibodies directed against Keratin K71, K72, K75, K82, K85 and K86 to evaluate the presence and status in IHC and WB.
The set contains enough antibody to perform stainings on 6-12 sections per antibody.

Set content:
Cat. No. GP-K6irs1S, anti-Keratin K71 guinea pig polyclonal, serum, sample, 600 µl
Cat. No. GP-G6irs2S, anti-Keratin K72 guinea pig polyclonal, serum, sample, 600 µl
Cat. No. GP-K6hfS, anti-Keratin K75 guinea pig polyclonal, serum, sample, 600 µl
Cat. No. GP-hHb2S, anti-basic Hair Keratin K82 guinea pig polyclonal, serum, sample, 600 µl
Cat. No. GP-hHb5S, anti-basic Hair Keratin K85 guinea pig polyclonal, serum, sample, 600 µl
Cat. No. GP-hHb6S, anti-basic Hair Keratin K86 guinea pig polyclonal, serum, sample, 600 µl

Reference

Reference

PublicationSpeciesApplicationAntibody
Langbein, L., Yoshida, H., Praetzel-Wunder, S., Parry, D. A. & Schweizer, J. The Keratins of the Human Beard Hair Medulla: The Riddle in the Middle. J. Invest. Dermatol. 130, 55–73 (2010). human IHC (frozen) GP-K6irs1, GP-K6irs2, GP-K6hf, GP-hHb2, GP-hHb6
Jennemann, R. et al. Integrity and Barrier Function of the Epidermis Critically Depend on Glucosylceramide Synthesis. J. Biol. Chem. 282, 3083–3094 (2006). mouse IHC (paraffin) GP-K6hf
Bazzi, H. et al. Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle. Differentiation 74, 129–140 (2006). human IHC (frozen) GP-hHb2
Peitsch, W. K. et al. Drebrin, an Actin-Binding, Cell-Type Characteristic Protein: Induction and Localization in Epithelial Skin Tumors and Cultured Keratinocytes. J. Invest. Dermatol. 125, 761–774 (2005). human IHC (frozen) GP-K6irs1, GP-K6hf
Langbein, L., Spring, H., Rogers, M. A., Praetzel, S. & Schweizer, J. Hair keratins and hair follicle-specific epithelial keratins. Methods Cell Biol 78, 413–451 (2004). human WB, IHC (frozen) GP-K6irs1, GP-K6hf, GP-hHb2, GP-hHb6
Langbein, L., Rogers, M. A., Praetzel, S., Winter, H. & Schweizer, J. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J. Invest. Dermatol. 120, 512–522 (2003). human WB, IHC (frozen) GP-K6irs2
Langbein, L. et al. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle. J. Invest. Dermatol. 118, 789–799 (2002). human WB, IHC (frozen), IEM GP-K6irs1, GP-K6hf
Langbein, L., Rogers, M. A., Winter, H., Praetzel, S. & Schweizer, J. The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins. J. Biol. Chem. 276, 35123–32 (2001). human WB GP-hHb2, GP-hHb6

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