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mouse brain (courtesy of J.Heß, University Hospital Heidelberg) Zoom

mouse brain (courtesy of J.Heß, University Hospital Heidelberg)

anti-Synaptophysin mouse monoclonal, SY38, prediluted, purified, ready-to-use

The anti-synaptophysin antibody SY38 stains neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas and neuroendocrine tumors of epithelial origin, e.g. pancreatic islet cell carcinoma, brochial and gastrointestinal carcinoids.
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Cat. No.: 65012
Quantity:  5 mL

Delivery Time: usually 1-7 working days

€139.00
Excl. 19% Tax, excl. Shipping Cost

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Specifications

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Product description

Host mouse
Antibody Type monoclonal
Isotype IgG1
Clone SY38
Immunogen Synaptophysin from presynaptic vesicles, prepared from bovine brain
Purification protein A affinity chromatography
Conjugate unconjugated
Formulation PBS pH 7.4 with 0.5% BSA and 0.09% sodium azide
Storage short term at 2 – 8 °C; long term storage in aliquots at - 20 °C; avoid freeze/ thaw cycles
Intended use Research use only
Tested species reactivity bovine, human, mouse, rat

Applications

Tested applications Tested dilutions
Immunocytochemistry (ICC)/ Immunofluorescence (IF) assay dependent
Immunohistochemistry (IHC) - frozen ready-to-use (in no case protease pretreatment)
Immunohistochemistry (IHC) - paraffin ready-to-use (in no case protease pretreatment)
Western Blot (WB) assay dependent

Background

Details

SY 38 represents an excellent marker for several neuroendocrine, neuronal and adrenal tumors. Neuronal and adrenal tumors such as pheochromocytomas, paragangliomas, neuroblastomas, ganglioneuroblastomas.
Neuroendocrine tumors of epithelial origin: Pancreatic islet cell carcinoma, bronchial and gastrointestinal carcinoids, medullary carcinoma of thyroid.
Polypeptide reacting: Mr 38 000 transmembrane glycoprotein of presynaptic vesicles.
Reactivity on cultured cell lines: Rat PC-12.

Reference

Reference

PublicationSpeciesApplication
Eispert, A.-C. et al. Evidence for distinct populations of human Merkel cells. Histochem. Cell Biol. 132, 83–93 (2009). human IHC (frozen)
Portela-Gomes, G. M., Stridsberg, M., Johansson, H. & Grimelius, L. Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract. Histochem. Cell Biol. 111, 49–54 (1999). human IHC (paraffin)
Chitaev, N. A. et al. The Binding of Plakoglobin to Desmosomal Cadherins: Patterns of Binding Sites and Topogenic Potential. J. Cell Biol. 113, 359–369 (1996). human WB
Leube, R. E. The topogenic fate of the polytopic transmembrane proteins, synaptophysin and connexin, is determined by their membrane-spanning domains. J. Cell Sci. 108, 883–894 (1995). human, rat WB, ICC-IF
Bennett, M. K., Calakos, N., Kreiner, T. & Scheller, R. H. Synaptic Vesicle Membrane Proteins Interact to Form a Multimeric Complex. J. Cell Biol. 116, 761–775 (1992). rat WB
Gould, V. E. et al. Synaptophysin Expression in Neuroendocrine Neoplasms as Determined by Immunocytochemistry. Am. J. Pathol.  126, 243–257 (1987). human IHC (frozen)
Gould, V. E. et al. Synaptophysin: a novel marker for neurons, certain neuroendocrine cells, and their neoplasms. Hum. Pathol. 17, 979–83 (1986). human IHC (paraffin)
Wiedenmann, B., Franke, W. W., Kuhn, C., Moll, R. & Gould, V. E. Synaptophysin: a marker protein for neuroendocrine cells and neoplasms. Proc. Natl. Acad. Sci. U. S. A. 83, 3500–4 (1986). human, bovine IHC (frozen)
Wiedenmann, B. & Franke, W. W. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell 41, 1017–28 (1985). mouse, bovine WB, IHC (frozen)

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